At Biomel, every formulation is grounded in research and intentionally crafted using ingredients with a purpose. We choose nutrients and functional compounds for their clinically researched benefits, ensuring they reflect the science that supports gut health, immunity and overall wellbeing.
Live cultures in yoghurt or fermented milk improve lactose digestion of the product in individuals who have difficulty digesting lactose
Source: Great Britain Nutrition & Health Claims (NHC) Register
Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial
Source: https://pubmed.ncbi.nlm.nih.gov/39093754/
Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study
Source: https://pubmed.ncbi.nlm.nih.gov/33545934/
Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults
A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation
Source: https://pubmed.ncbi.nlm.nih.gov/35079761/
Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial
A double blinded randomized placebo trial of Bifidobacterium animalis subsp. lactis BLa80 on sleep quality and gut microbiota in healthy adults
Source: https://www.nature.com/articles/s41598-025-95208-2
Bifidobacterium animalis subsp. lactis TISTR 2591 Improves Glycemic Control and Immune Response in Adults with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial
Source: https://www.mdpi.com/2072-6643/17/19/3097
Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial
Multi-omics analyses the effect of Bifidobacterium longum subsp. longum BL21 supplementation on overweight and obese subjects: a randomized, double-blind, placebo-controlled study
Source: https://pubmed.ncbi.nlm.nih.gov/40676704/
Bifidobacterium longum CCFM1077 Attenuates Hyperlipidemia by Modulating the Gut Microbiota Composition and Fecal Metabolites: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Source: https://www.sciencedirect.com/science/article/pii/S2095809923002059
The Impact of Fermented Milk Products Containing Bifidobacterium longum BB536 on the Gut Environment: A Randomized Double-Blind Placebo-Controlled Trial
Source: https://pubmed.ncbi.nlm.nih.gov/39519413/
Influence of Bifidobacterium longum CECT 7347 and gliadin peptides on intestinal epithelial cell proteome
Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects
Source: https://pubmed.ncbi.nlm.nih.gov/20815975/
Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia
Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women
Source: https://pubmed.ncbi.nlm.nih.gov/38687069/
Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects
Source: https://pubmed.ncbi.nlm.nih.gov/22645023/
Probiotic supplement (Lactobacillus acidophilus and bulgaricus) utility in the treatment of irritable bowel syndrome
Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players
Source: https://pubmed.ncbi.nlm.nih.gov/40353739/
Effect of Lacticaseibacillus casei LC2W Supplementation on Glucose Metabolism and Gut Microbiota in Subjects at High Risk of Metabolic Syndrome: A Randomized, Double-blinded, Placebo-controlled Clinical Trial Source: https://pubmed.ncbi.nlm.nih.gov/38954305/
The role of probiotics in improving menstrual health in women with primary dysmenorrhoea: A randomized, double-blind, placebo-controlled trial (the PERIOD study)
Vaginal colonisation by probiotic lactobacilli and clinical outcome in women conventionally treated for bacterial vaginosis and yeast infection
Source: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-0971-3
Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
Source: https://pubmed.ncbi.nlm.nih.gov/29688793/
Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial
Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study
Source: https://pubmed.ncbi.nlm.nih.gov/32326347/
Impact of Lactocaseibacillus (Lactobacillus) paracasei sup. paracasei TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial
Source: https://pubmed.ncbi.nlm.nih.gov/39275232/
Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study
Source: https://pubmed.ncbi.nlm.nih.gov/20697291/
An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults
Source: https://pubmed.ncbi.nlm.nih.gov/29228000/
Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism
Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial
Source: https://pubmed.ncbi.nlm.nih.gov/38427038/
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial
Source: https://onlinelibrary.wiley.com/doi/10.1111/joim.12805
Supplementation with Lactobacillus reuteri ATCC PTA 4659 in patients affected by acute uncomplicated diverticulitis: a randomized double-blind placebo controlled trial
Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial
Source: https://pubmed.ncbi.nlm.nih.gov/40527514/
Strain specific effects of probiotic supplementation on serum amino acid profiles in Alzheimer's disease: a randomized, double blind, placebo controlled trial
Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women
Source: https://pubmed.ncbi.nlm.nih.gov/38687069/
Streptococcus thermophilus fermented milk reduces serum MDA-LDL and blood pressure in healthy and mildly hypercholesterolaemic adults
Macronutrients
Carbohydrates contribute to the recovery of normal muscle function (contraction) after highly intensive and/or long-lasting physical exercise leading to muscle fatigue and the depletion of glycogen stores in skeletal muscle
Source: Great Britain Nutrition & Health Claims (NHC) Register
Protein contributes to a growth in muscle mass
Protein contributes to the maintenance of muscle mass
Protein contributes to the maintenance of normal bones
Protein is needed for normal growth and development of bone in children.
Source: Great Britain Nutrition & Health Claims (NHC) Register
ALA contributes to the maintenance of normal blood cholesterol levels
DHA contributes to maintenance of normal brain function
DHA and EPA contribute to the maintenance of normal blood pressure
DHA and EPA contribute to the normal function of the heart
Source: Great Britain Nutrition & Health Claims (NHC) Register
Dietary Fibre
Fruits and their impact on the gut microbiota, gut motility and constipation
Consumption of beta-glucans from oats or barley as part of a meal contributes to the reduction of the blood glucose rise after that meal
Oat beta-glucan has been shown to lower/reduce blood cholesterol. High cholesterol is a risk factor in the development of coronary heart disease
Source: Great Britain Nutrition & Health Claims (NHC) Register
Effect of dietary supplementation with oat β-glucan for 3 months in subjects with type 2 diabetes: A randomized, double-blind, controlled clinical trial
Source: https://www.sciencedirect.com/science/article/pii/S1756464620305351
Chicory inulin contributes to normal bowel function by increasing stool frequency
Source: Great Britain Nutrition & Health Claims (NHC) Register
Guar gum contributes to the maintenance of normal blood cholesterol levels
Source: Great Britain Nutrition & Health Claims (NHC) Register
Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial
Source: https://pubmed.ncbi.nlm.nih.gov/31509971/
Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome
Oat grain fibre contributes to an increase in faecal bulk
Source: Great Britain Nutrition & Health Claims (NHC) Register
Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial
Polydextrose and soluble corn fiber increase five-day fecal wet weight in healthy men and women
Enzymes
Lactase enzyme improves lactose digestion in individuals who have difficulty digesting lactose
Source: Great Britain Nutrition & Health Claims (NHC) Register
Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study
Vitamins & Minerals
Calcium contributes to normal energy-yielding metabolism
Calcium contributes to normal neurotransmission
Calcium contributes to the normal function of digestive enzymes
Calcium has a role in the process of cell division and specialisation
Source: Great Britain Nutrition & Health Claims (NHC) Register
Magnesium contributes to a reduction of tiredness and fatigue
Magnesium contributes to electrolyte balance
Magnesium contributes to normal energy-yielding metabolism
Magnesium contributes to normal functioning of the nervous system
Magnesium contributes to normal muscle function
Magnesium contributes to normal protein synthesis
Magnesium contributes to normal psychological function
Magnesium contributes to the maintenance of normal bones
Magnesium contributes to the maintenance of normal teeth
Magnesium has a role in the process of cell division
Source: Great Britain Nutrition & Health Claims (NHC) Register
Vitamin B6 contributes to normal cysteine synthesis
Vitamin B6 contributes to normal energy-yielding metabolism
Vitamin B6 contributes to normal functioning of the nervous system
Vitamin B6 contributes to normal homocysteine metabolism
Vitamin B6 contributes to normal protein and glycogen metabolism
Vitamin B6 contributes to normal psychological function
Vitamin B6 contributes to normal red blood cell formation
Vitamin B6 contributes to the normal function of the immune system
Vitamin B6 contributes to the reduction of tiredness and fatigue
Vitamin B6 contributes to the regulation of hormonal activity
Source: Great Britain Nutrition & Health Claims (NHC) Register
Vitamin B12 contributes to normal energy-yielding metabolism
Vitamin B12 contributes to normal functioning of the nervous system
Vitamin B12 contributes to normal homocysteine metabolism
Vitamin B12 contributes to normal psychological function
Vitamin B12 contributes to normal red blood cell formation
Vitamin B12 contributes to the normal function of the immune system
Vitamin B12 contributes to the reduction of tiredness and fatigue
Vitamin B12 has a role in the process of cell division
Source: Great Britain Nutrition & Health Claims (NHC) Register
Vitamin D contributes to normal absorption/utilisation of calcium and phosphorus
Vitamin D contributes to normal blood calcium levels
Vitamin D contributes to the maintenance of normal bones
Vitamin D contributes to the maintenance of normal muscle function
Vitamin D contributes to the maintenance of normal teeth
Vitamin D contributes to the normal function of the immune system
Vitamin D has a role in the process of cell division
Vitamin D helps to reduce the risk of falling associated with postural instability and muscle weakness. Falling is a risk factor for bone fractures among men and women 60 years of age and older.
Vitamin D contributes to the normal function of the immune system in children.
Vitamin D is needed for normal growth and development of bone in children.
Source: Great Britain Nutrition & Health Claims (NHC) Register
Zinc contributes to normal DNA synthesis
Zinc contributes to normal acid-base metabolism
Zinc contributes to normal carbohydrate metabolism
Zinc contributes to normal cognitive function
Zinc contributes to normal fertility and reproduction
Zinc contributes to normal macronutrient metabolism
Zinc contributes to normal metabolism of fatty acids
Zinc contributes to normal metabolism of vitamin A
Zinc contributes to normal protein synthesis
Zinc contributes to the maintenance of normal bones
Zinc contributes to the maintenance of normal hair
Zinc contributes to the maintenance of normal nails
Zinc contributes to the maintenance of normal skin
Zinc contributes to the maintenance of normal testosterone levels in the blood
Zinc contributes to the maintenance of normal vision
Zinc contributes to the normal function of the immune system
Zinc contributes to the protection of cells from oxidative stress
Zinc has a role in the process of cell division
Source: Great Britain Nutrition & Health Claims (NHC) Register
